Abstract
A complete solid-state study of the drug quinacrine dihydrochloride has highlighted the existence of two anhydrous phases and a tetrahydrate form, using water sorption experiments, thermal analysis techniques, and crystallographic studies. The tetrahydrate crystal obtained by crystal growth from a water/dioxane (80:20, v/v) solution has been characterized by single-crystal X-ray diffraction at 123 K. This phase is a complex three-dimensional hydrogen bonding network, including four water molecules and two free chloride ions, and crystallizes in the P1 space group. Because no filiation between the two hydrates has been evidenced yet, the dehydration–rehydration mechanism has been evaluated for the present study as a destructive–reconstructive process. Two related anhydrous phases were also characterized by X-ray powder diffraction and thermal analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
