Abstract
The opioid peptides Methionine enkephalin and β-Endorphin are stimulators of Natural Killer cytolytic activity. To know the biochemical mechanisms that explain this action, the binding of Methionine enkephalin and Naloxone in presence or ausence of Na+ ion and GTP to human Lymphocyte membranes was characterized.
Highlights
Our immune system has diverse defense mechanisms that can be classified as a humoral and cellular responses, that is, the production of diversity of antibodies by the a B Lymphocyte and others cells capable of recognizing and destroying other cells such as Natural Killer (NK) cells, which constitute a subpopulation of lymphocytes with the ability to destroy tumoral or viral infected cells, without prior sensitization or restriction of the Histocompatibility Major Antigen type
The NK cells correspond morphologically to large granular lymphocytes and represent a minor but important proportion of total circulating mononuclear cells [1,2]. This Natural Killer Cell Activity (NKCA) which decreases markedly in pathologies such as leukemia, immunodeficiency and sepsis [2,3] has been the subject of extensive research in recent years, evidencing the existence of several modulators such as several lymphokines, especially IL-2 and IFN (α, β, γ) [4,5] which promote either the proliferation of NK cells and/or their stimulation [6,7]
Signals from the target cell promote the activation of the secretory system of the NK cell and soluble factors such as NKCF are released to produce the final lysis of the target cell [32,45,46]
Summary
Our immune system has diverse defense mechanisms that can be classified as a humoral and cellular responses, that is, the production of diversity of antibodies by the a B Lymphocyte and others cells capable of recognizing and destroying other cells such as Natural Killer (NK) cells, which constitute a subpopulation of lymphocytes with the ability to destroy tumoral or viral infected cells, without prior sensitization or restriction of the Histocompatibility Major Antigen type. The NK cells correspond morphologically to large granular lymphocytes and represent a minor but important proportion of total circulating mononuclear cells [1,2] This Natural Killer Cell Activity (NKCA) which decreases markedly in pathologies such as leukemia, immunodeficiency and sepsis [2,3] has been the subject of extensive research in recent years, evidencing the existence of several modulators such as several lymphokines, especially IL-2 and IFN (α, β, γ) [4,5] which promote either the proliferation of NK cells and/or their stimulation [6,7].
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