Abstract
Sequencing-based typing of HLA-DRB1 gene, allowed us to characterize three new alleles. DRB1*03:55 shows one nucleotide change regarding DRB1*03:01:01G, resulting in an amino acid replacement at position 80 R > I. DRB1*11:46:02 presents one synonymous nucleotide change at codon 34 (CAG > CAA) with regard to DRB1*11:46:01. Finally, DRB1*04:92 has one nucleotide change from DRB1*04:07:01 at codon 207 in exon 4, producing an amino acid replacement (V > M) in the transmembrane domain.
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