Abstract
Multivalent signaling proteins contain multiple domains/motifs that serve as recognition sites for the assembly of multi-protein complexes which modulate signal transduction, as well as integrate diverse signaling networks for critical cellular functions. In Drosophila, the tumor suppressor protein, Warts functions as a hub for the assembly of a regulatory complex which controls cell proliferation, and apoptosis in Hippo signaling. Warts, a serine-threonine kinase contains five proline-rich motifs of type PPXY (where X is any amino acid) which mediate protein-protein interactions with tandem WW domains in the transcriptional co-activator, Yorkie, and the tumor suppressor, Salvador.
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