Abstract
The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity.
Highlights
The group under the generic name “rattlesnake” (Crotalus) constitutes a monophyletic group of snakes next to the genus Sistrurus
The chromatographic profiles of C. d. cumanensis compared to the pool
The results obtained with antivenom in immunodepletion and Western blot show immunorecognition of the proteins of C. d. cumanensis venom, this recognition does not imply good neutralization of the effects of the venom in vivo; it is necessary to carry out neutralization tests in vivo
Summary
The group under the generic name “rattlesnake” (Crotalus) constitutes a monophyletic group of snakes next to the genus Sistrurus It is characterized by the presence of a cornified structure derived from the ecdysis (molting) in its tail and by its wide geographic distribution from the southeast of Canada to the north of Argentina. This genus includes the species Crotalus durissus (C. d.), with at least. South American rattlesnake is composed ofcomplex a complexmixture mixture of of peptides, peptides, enzymes, enzymes, and toxins. Crotamine, gyroxine, convulxin, a thrombin-like enzyme [3,4], and thecomplex crotoxin(composed complex
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