Abstract
BackgroundMeteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet.MethodsThe present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits.ResultsMetrnl concentration was considerably lower in both UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups.ConclusionsThe current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.
Highlights
Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently
Regarding to the fact that Inflammatory Bowel Disease (IBD) is an inflammatory disease and Metrnl anti-inflammatory activities, in this study, the levels of Metrnl in serum were examined in the patients with inflammatory bowel disease and its association was assessed with the hall-markers of inflammatory cytokines, interleukin (IL)-6, and Tumor necrosis factor (TNF-α). Study population This case-control study was conducted on 54 control subjects (42 male and 12 female) and 85 IBD patients including 42 ulcerative colitis (UC) (31 male and 11 female) and 43 Crohn’s disease (CD) (28 male and 15 female) who were recruited from endoscopy unit of Valiasr Hospital, Birjand, Iran
There is no significant difference in terms of age, sex, and body mass index (BMI)
Summary
Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. Inflammatory Bowel Disease (IBD) as one of the causes of mortality in modern societies, characterized by gastrointestinal chronic inflammation [1, 2]. Recent epidemiological studies have shown that incidence of IBD is rising in parallel with obesity prevalence [4, 5]. Scientific studies have suggested that, genetics, gut microbiome, and the immune system may play critical roles in IBD, this has not completely understood yet [7]. IBD (UC and CD) displays the characteristics of chronic inflammation and metabolic syndrome, that induces effective changes in metabolism [8, 9]. IBD can be considered as a risk factor for obesity via changing in the intestinal microbial metabolism [9, 12]
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