Abstract
The discontinuous synthesis of polyoma DNA in infected isolated nuclei from 3T6 cells is initiated with RNA. From experiments in which this RNA was labelled from [3H] or β-[32P] labelled ribonucleoside triphosphates we conclude that the 5′ end of initiating RNA starts with ATP or GTP, but not with CTP or UTP. When the RNA was released from progeny DNA strands by digestion with pancreatic DNAse and characterized by gel electrophoresis its position on the gel corresponded approximately to that of a decanucleotide. While initiating RNA was quite homogenous in size it had no unique nucleotide sequence.
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