Abstract

1. The renal clearance of p-aminohippurate (PAH) is the most commonly used method for estimation of renal blood flow in laboratory animals and in humans. 2. This study characterizes the renal handling of PAH in 11 beagle dogs and describes for this species critical parameters for the valid use of the renal PAH clearance technique to estimate renal blood flow. 3. PAH was given as a priming dose plus infusion rates of 0.01–6 mg/kg per min. 4. Steady-state plasma concentrations were achieved within 60 min. 5. Urinary excretion of PAH accounted for ⩾-90% of the PAH infused. 6. Plasma PAH concentrations increased linearly with dose. 7. Renal secretion of PAH exceeded filtered PAH at plasma PAH concentrations less than approx. 6 mg%. 8. The Tm PAH for renal PAH secretion was approx. 0.4 mg/kg per min. 9. At PAH infusion rates above Tm PAH the clearance of PAH decreased and asymptotically approached the value of the GFR.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.