Abstract
The present investigation was aimed at elucidating if μ-, δ- and κ-opioid receptors are involved in the effects of DAMGO (selective μ-agonist), DPDPE (selective δ-agonist) and U50,488H (selective κ-agonist) in isolated electrically driven human right atria strips. The negative inotropic effects induced by the opioid agonists used in this study were not antagonized in presence of naloxone (preferentially μ-antagonist), naltrindole (selective δ-antagonist) and norbinaltorphimine (selective κ-antagonist). These data suggest that the opioid receptors are not involved in the cardiac depressant effects induced by μ-, δ- and κ-opioid agonists.
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