Abstract
The prejunctional muscarine receptor on sympathetic nerves in the rat caudal artery was characterized using several selective antagonists. The inhibitory response of carbachol on vasoconstriction elicited by sympathetic nerve stimulation was antagonized by benzhexol (trihexyphenidyl; p K B 7.1), heptane-1,7-bis(dimethyl-3′-phthalimidopropyl ammonium bromide) (C 7/3-phth; p K B 6.5) and hexahydrosiladifenidol (HHSiD; apparent p K B 6.0) values suggest that the receptor most closely resembles the muscarine M 2 receptor subtype rather than the muscarine M 1, M 3 or M 4 receptor subtypes.
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