Abstract
1. 1. The effect of membrane stretch (applied via patch pipette suction) on the activity of a single stretch-activated K + (SAK) channel in patch-clamped, isolated Lymnaea stagnalis heart ventricle muscle cells was examined. 2. 2. SAK channel kinetics were described by two stretch-insensitive open-dwell time constants with means of 0.58 and 6.43 msec, two stretch-insensitive closed-dwell time constants with means of 0.023 and 0.569 msec, and one long-lived stretch-sensitive closed-dwell time constant (range 77–248 msec). 3. 3. We conclude that the membrane-stretch-induced increase in activity in the SAK channel, and the apparent increase in burst duration, can be attributed solely to changes in the long-lived closed time constant.
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