Characterization of the influence of Amyloid β (1-42) By Way of Modeling Synaptic Cleft with an RC Electronic Circuit

Abstract

The research toward understanding the role of oligomeric amyloids in Alzheimer disease (AD) has gained a considerable attention in recent years. The information obtained in this direction showed that Amyloid Derived Diffusible Ligands (ADDLs) cause an ambiguous ions movements across lipid bilayers in plasma membrane and consequently alter its dielectric properties such as permeability. Nevertheless, how these amyloid protein selectively alters the permeability of cell membrane has not been noted down because none of specific receptor have been identified for ADDLs binding. As a result of the increase of cellular calcium level, local micromechanical properties of cells can change and thus induce reorganization of cytoskeletal structures that can cause neurodegenerative disorders such as AD. Therefore, in this study we have tried to specify the effect of alteration of permittivity and permeability of synaptic channel as modelling synaptic cleft by an RC circuit. By linking the electronic neuronal models that we have previously designed with the RC cleft model, when the information transferred from one neuron to another, the rate of error measured on the later neuron circuit with reference of the former one was determined with respect to the rate of change of R and C values individually. It was observed that C and R, and hence permeability of synaptic channel does effect the communication error. It is concluded that a healthy synaptic channel conserves optimum resistivity and capacity levels at which the inter-neuronal signalling is achieved at a minimum error. This results could be linked to hypothesizes that amyloids have a common feature in structuring channel-like concentrations which supported by their electrical activity as well as the rate of permeability of Calcium like cautions.