Abstract
Seven daily intraperitoneal doses (0.25 mg/kg) of the antibiotics muconomycin A (M-A) or muconomycin B (M-B) induced large volumes (10–20 ml) of peritoneal inflammatory exudate in rats. This exudate had the same general electrolyte and protein composition as has been reported for other mammalian edema fluids. In both antibiotic-treated groups the exudate contained lower concentrations of sodium, albumin, and globulin, and greater amounts of potassium, calcium, and phosphorus, than did blood serum. M-B-treated rats had lower chloride levels in exudate than in serum. Both antibiotics cause polymorphonuclear neutrophilia and lymphopenia, conditions characteristic of an inflammatory state in the rat. Both antibiotics appear to be among the most potent nonnitrogenous compounds known to induce inflammation.
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