Abstract
The distribution of label into newly synthesized double-stranded (ds) RNA in replicase particles isolated from reovirus-infected cells at 7.5 hr postinfection was determined. A 30-min exposure of infected cells to [ 3H]uridine labeled the RNA in both (+) and (−) strands. These results indicate that any single-stranded (ss) RNA that is made at later times postinfection and that associates with replicase particles can function as the template for the synthesis of dsRNA.
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