Abstract
The promoter of the chicken α1(VI) collagen gene resembles the 5′‐flanking regions of many housekeeping genes. It lacks a canonical TATAA box but contains potential binding sites for transcription factors AP1 and SP1. The promoter region has a relatively high GC content and forms a typical CpG island. In accordance with the absence of a TATAA element, the gene contains multiple transcription‐initiation sites distributed over 80 bp genomic DNA. A 621‐bp fragment derived from the 5′ end of the α1(VI) collagen gene is able to direct transcription of a heterologous reporter gene in transient‐expression assays. Other DNA fragments that are either shorter or longer than the 621‐bp fragment show markedly reduced promoter activity. Thus, the basic promoter element of the α1(VI) collagen gene must reside within this 621‐bp fragment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
