Characterization of the Causative Allergens for Wheat-Dependent Exercise-Induced Anaphylaxis Sensitized with Hydrolyzed Wheat Proteins in Facial Soap

Abstract

Hydrolyzed wheat proteins (HWP) were reported to cause wheat-dependent exercise-induced anaphylaxis (WDEIA) by transcutaneous sensitization through the use of HWP-containing soap in Japan. These patients developed the allergic reactions not only with the use of soap, but also on exercise after the intake of wheat protein (WP). In this study, we identified the allergens and its IgE-binding primary epitopes in WP for HWP-WDEIA patients.