Year-end Sale % OFF 
Abstract
Asthma is a chronic inflammatory disease characterized by bronchial hyperresponsiveness, mucus overproduction and airway remodeling. Notably, we have recently demonstrated that insulin-like growth factor 1 receptor (IGF1R) deficiency in mice attenuates airway hyperresponsiveness and mucus secretion after chronic house dust mite (HDM) exposure. On this basis, inbred C57BL/6 and Igf1r-deficient mice were given HDM extract to study the acute inflammatory profile and implication of Igf1r in acute asthma pathobiology. Additionally, Igf1r-deficiency was therapeutically induced in mice to evaluate the resolution of HDM-induced inflammation. Acute HDM exposure in inbred C57BL/6 mice led to a progressive increase in inflammation, airway remodeling and associated molecular indicators. Preventively-induced Igf1r-deficiency showed reduced neutrophil and eosinophil numbers in BALF and bone marrow, a significant reduction of airway remodeling and decreased levels of related markers. In addition, therapeutic targeting of Igf1r promoted the resolution of HDM-induced-inflammation. Our results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM-induced inflammation. Thus, IGF1R is suggested to be a promising candidate for future therapeutic approaches for the treatment and prevention of asthma.
Highlights
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), mucus overproduction and airway wall remodeling [1]
Inbred C57BL/6 mice were subjected to an acute House dust mite (HDM) exposure to study the progressive changes in bronchoalveolar lavage fluid (BALF) and lung (Fig 1A)
Lung mRNA expression analysis demonstrated a significant up-regulation of the allergic airway inflammation markers Il33, Cd4, Il4, Il10, Il13, Ccl11, Ccl2, Cxcl1, Tnf and Il1b in addition to the airway remodeling indicators Acta2, Muc5ac and Col1a1
Summary
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), mucus overproduction and airway wall remodeling [1]. House dust mite (HDM)derived allergens and those arising from the species Dermatophagoides pteronyssinus are the most important source of mite-related allergens in asthmatic patients [2]. Acute inflammatory profile and resolution of inflammation after Igf1r-gene targeting in a HDM model of asthma research foundation, the Karolinska Institutet, and the Centre for Allergy Research at Karolinska Institutet to MA
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
