Abstract
The reactions of metal ions such as copper (II), cobalt (II), nickel (II), and cerium (IV) with 15 sulfonamides on TLC plates were examined to obtain a suitable reagent for the visualization of these drugs. A solution of copper acetate in methanol produces spots of varying colors, whereas an acidic solution of ceric sulfate gives yellow or purple spots with all the sulfonamides studied. Cobalt (II) and nickel (II) are specific for a limited number of sulfonamides.
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