Abstract
This study aims to detect Staphylococcus aureus (S. aureus) resistance in the veterinary hospital environment. S. aureus are one of the components of the microbiota, and they may be present in patients in a veterinary hospital environment. Methicillin resistance is determined by a chromosomal gene (mecA), which codes for modifications in the beta-lactam antibiotic receptor, where the penicillin-binding protein will have a low affinity for the antibiotic. Samples were collected through swabs of materials and equipment at the hospital. S. aureus was identified in 7.6% (21/276) of the samples collected, and of the 21 strains isolated, 4 (19.0%) carried the mecA gene. MRSA are all strains of S. aureus that express the mecA gene. Four strains harbor the mecA gene; however, only two expressed the phenotypic resistance to cefoxitin and were characterized as MRSA. An isolate (strain 18) present on a patient care table was identified as methicillin-resistant S. aureus with intermediate sensitivity to vancomycin (VISA). Our observations suggest the need for containment measures (good antisepsis practices) to avoid the possible transmission of resistant bacterial agents for the veterinary hospital environment.
Highlights
Staphylococcus sp. represents one of the main groups of microorganisms involved in human or animal infections
Penicillin and its derivatives, including methicillin, have been used for the treatments of infections caused by this microorganism; certain strains developed resistance known as Methicillin-Resistant Coagulase-Negative Staphylococci (MRS) and methicillin-resistant S. aureus (MRSA). is resistance to methicillin is determined by the mecA gene, which encodes the low affinity penicillin-binding protein PBP 2 [1]. e prevalence of MRSA/MRS strains in infections has increased worldwide, and an alternative treatment has been the use of na antibiotic glycopeptides such as vancomycin
It has emerged as another resistant profile of these microorganisms, the methicillinresistant S. aureus with intermediate sensitivity to vancomycin (VISA). ese bacteria may be disseminated to the community through colonized medical staff or discharged patients. e emergence and spread of MRSA in the community, independent of the healthcare setting and in the absence of typical risk factors for nosocomial MRSA infections, are matters of further concern [2]
Summary
Staphylococcus sp. represents one of the main groups of microorganisms involved in human or animal infections. E prevalence of MRSA/MRS strains in infections has increased worldwide, and an alternative treatment has been the use of na antibiotic glycopeptides such as vancomycin. Penicillin and its derivatives, including methicillin, have been used for the treatments of infections caused by this microorganism; certain strains developed resistance known as Methicillin-Resistant Coagulase-Negative Staphylococci (MRS) and methicillin-resistant S. aureus (MRSA). It has emerged as another resistant profile of these microorganisms, the methicillinresistant S. aureus with intermediate sensitivity to vancomycin (VISA). Prevention of further dissemination of MRSA with a zoonotic potential needs concerted action of veterinary infection control specialists and clinicians [3, 7], but it is necessary to obtain information regarding the prevalence of MRSA infection before implementing strategies for infection control in veterinary medical practice. e data presented in the present study could provide some information regarding the transmission of MRSA/VISA in a veterinary hospital environment
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