Abstract
In vivo binding of 3H-spiperone is saturable in the striatum, the limbic system and the frontal cortex but not in the cerebellum. A specific binding is different in all the brain regions thus the amount of labelling in the cerebellum may not be considered as a blank value. 3H-spiperone binding revealed a specific subcellular distribution only when a very low dose was injected into rats. Ex vivo experiments allow the assessment of biochemical profiles of neuroleptic drugs according to their relative affinity for dopamine or serotonin receptors.
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