Abstract
Two types of binding sites for high-density lipoproteins (HDL): P1 and P2 Kdl=20 and Kd2=2.5μg/ml, N1=130 and N2=35 ng/mg cell protein) are identified on the surface of rat hepatocytes. Conditions for predominant determination of P2 are created by employing radiolabeled lipoproteins (125I-HDL) with a high specific activity (1000 dpm) and the differences in the kinetics of the P1-and P2-125I-HDL complex formation. P2 predominate on hepatocytes from females. The addition of estradiol to a culture of hepatocytes from males increases the content of P2, while the addition of testosterone to hepatocytes from females decreases the content of P2 to the levels determined in males.
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