Abstract
In this study, we synthesized deep eutectic solvents (DESs) based on sucrose with citric acid, choline chloride, and proline by an evaporating method. The structural features and thermal behaviors of the DESs were further characterized by polarized optical microscopy (POM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). The experimental data showed that the physicochemical properties of DES were closely related to their water content. Furthermore, the solubility of piroxicam in DESs was studied by the shake-flask method at 30–45 °C. Results indicated that the drug solubility was enhanced with an increase in the proportion of DESs and temperature. Piroxicam was dissolved more than 2420 times compared with pure water in the presence of sucrose/citric acid (1:1) with 30 % (w/w) water content when the temperature was 45 °C. Cell counting kit-8 assay was applied to determine the cytotoxicity of the DESs. Cell experiments showed that these solvents were highly biocompatible in mouse fibroblasts. This information supported that sucrose-based DESs have potential and provided new insight into a wide range of sucrose applications.
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