Abstract
Simvastatin, lipophilic statin, is the most commonly used drugs to treat hyperlipidaemia. Recent studies reported that they have both adverse and beneficial effects on kidney. However these results are contradictory. In this study, the aim was to investigate the effects of simvastatin on concentration, structure and function of molecules of kidney brush border membrane (BBM) by Attenuated Total Reflectance‐Fourier Transform Infrared (ATR‐FTIR) spectroscopy and chemometric analysis.During 30 days, control and simvastatin treated rats were taken serum physiologic and 50 mg/kg/day simvastatin intragastrically, respectively. Simvastatin‐induced changes in the structure and function of molecules in kidney BBM were determined from the frequency, area and width analysis of spectral bands. Based on these alterations, cluster and principal component analysis (PCA) were applied to discriminate these groups. Moreover, artificial neural network (ANN) analysis was used to determine the secondary structure alterations in proteinsSpectral analysis indicated a decrease in the amount of saturated and unsaturated lipids and proteins with simvastatin treatment. Control and simvastatin groups were successfully distinguished. A significant decrease in beta sheet and increase in random coil content were observed in simvastatin treated group. This study was supported by BAP‐08–11‐DPT‐2011K121010.
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