Abstract
The gut is the most common site of all primary extranodal lymphomas, accounting for roughly 5% of nonHodgkin’s lymphoma. Anaplastic large-cell lymphoma (ALCL) is characterized by a cohesive, solid growth pattern of large lymphoma cells closely resembling anaplastic carcinoma and intense expression of CD30 (Ki-1) antigen in the neoplastic cells of Tand/or null-cell origin. ALCL can be divided into two major groups: anaplastic lymphoma kinase (ALK) positive and ALK negative. ALK expression, the result of a t(2;5) translocation, is strongly associated with younger age and a good prognosis. Primary gastric ALCL is found sporadically; the typical endoscopic finding is a large mass with ulceration similar to an advanced cancer. By contrast, secondary GI lesions with systemic ALCL are exceptionally infrequent, with only a few published reports. However, these reports do not focus on the GI lesions; furthermore, gastroenteric involvement by ALCL has not been reported. This report describes two patients with secondary GI involvement by ALK-positive systemic ALCL.
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