Abstract
We report an isothermal flow calorimeter for characterization of reaction enthalpy and kinetics.
Highlights
In this manuscript we describe a microfluidic platform for characterization of enthalpy and kinetics of chemical reactions
We chose the hydrolysis of acetic anhydride to acetic acid as the model reaction to test the calorimeter (Fig. 5)
It often serves as a model reaction for calorimetry and has been thoroughly studied in literature, with the enthalpy and kinetics well known.[45,46,47,48,49,50]
Summary
In this manuscript we describe a microfluidic platform for characterization of enthalpy and kinetics of chemical reactions. For highly exothermic processes, accurate enthalpy and kinetics data are essential to find safe and optimal operating conditions. This is usually achieved via batch experimentation, often requiring large volumes of reactants. To address this problem, we envisioned application of microreactors to realize a continuous flow platform for calorimetric and kinetic measurements. Microfluidic devices offer excellent heat transfer due to high surface-to-volume ratio,[1] enabling investigation of reactions at elevated reactant concentrations when compared to standard equipment, which in turn means that lower overall reagent volumes suffice to achieve a measurable heat output. Several studies have already demonstrated such advantageous coupling of analytical and microfluidic technologies, including e.g. a high-throughput oscillatory droplet reactor to probe reaction space for optimal conditions;[6,7,8] and a self-optimising automated flow API synthesis with an at-line HPLC for sample analysis.[9]
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