Abstract
The damage caused by ionizing radiation and by autoxidation processes to the base moiety of deoxydinucleoside monophosphates d(TpA) and d(GpC) exposed in oxygenated solutions has been investigated. The same principal products are generated by both modalities. The products generated in largest yield have been identified as formamide and imidazolidine modifications derived from damaged thymine and cytosine moieties, respectively. These radiation-induced and autoxidation-induced lesions have been isolated by HPLC and characterized by 1H NMR spectroscopy including two-dimensional COSY spectroscopy. The possible biological significance of these lesions is discussed.
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