Characterization of propofol in human breath of patients undergoing anesthesia

Abstract

Ion mobility spectrometry coupled to a multi-capillary column (MCC/IMS) was used in anesthesia to detect signals related to Propofol in the breath directly. First time both positive and negative ions were investigated. It was found, that the detection limit in the negative mode is lower as in the positive one. Results of experiments with and without a bolus of Propofol were discussed with respect to kinetic models.