Abstract
BackgroundMeningiomas are the single most common brain tumor. The incidence of these tumors increases with age; different studies have shown that meningiomas usually appear after the age of 50. These tumors are more common in women than in men, and women are twice as likely to suffer from the condition. Surgery is the primary form of treatment, which can be curative with complete resection. If the tumor is unresectable or other treatments such as surgery and radiotherapy have failed, hormonal therapy or chemotherapy may be considered. There is limited information about the clinical, demographic, and histopathological characteristics of these tumors in the population of Bogotá, Colombia.ObjectiveTo evaluate the expression of progesterone receptors in patients over 18 years old who have been diagnosed with meningiomas in a high-complexity hospital in Bogota, Colombia, and to describe the demographic and histopathological characteristics of these patients.MethodsThis is a descriptive and retrospective case series. Patients with meningioma who underwent surgical resection at a high-complexity hospital in Bogota, Colombia, from 2016 to 2019 were retrospectively identified and studied. Demographic variables, such as age and gender, were extracted from the clinical chart. Indirect immunoperoxidase staining was carried out for the progesterone receptor (PR) and Ki67. PR is analyzed as positive and negative, and the Ki67 proliferation index was determined.ResultsThirty-two meningiomas from patients who underwent surgery were available for analysis. Twenty-five (78.1%) were positive for PR, 71.8% were females, and 93% were World Health Organization (WHO) grade I. Meningothelial (28%), fibrous (25%), and transitional (25%) meningiomas were the most frequent subtypes, correspondingly. The Ki67 mean value was 1.14 (0.11-10.71).ConclusionOur case series showed a greater frequency of meningiomas in women, with a high PR expression and a low Ki67 proliferation rate. These data correlate with literature worldwide.
Highlights
Meningiomas are the single most common brain tumor, comprising approximately 36.5% of all primary brain tumors [1,2]
Thirty-two meningiomas from patients who underwent surgery were available for analysis
We found six lateral skull base meningiomas, out of which 83.3% were positive for progesterone receptor (PR), and 23 non-skull base meningiomas, from which 78.3% were positive for PR
Summary
Meningiomas are the single most common brain tumor, comprising approximately 36.5% of all primary brain tumors [1,2]. Different studies have shown that meningiomas appear more frequently in later life, after the age of 50. These tumors are more common in women who are twice as likely as men to suffer from the condition if both genders are compared [4,5]. Meningiomas are the single most common brain tumor The incidence of these tumors increases with age; different studies have shown that meningiomas usually appear after the age of 50. These tumors are more common in women than in men, and women are twice as likely to suffer from the condition. There is limited information about the clinical, demographic, and histopathological characteristics of these tumors in the population of Bogotá, Colombia
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