Characterization of polyvinyl alcohol-nanocellulose composite film and its release effect on tetracycline hydrochloride

Abstract

Desmodium intortum(Mill.) Urb. is an important source of organic fertilizers, but its utilization value has not been developed favorably. The utilization of polyvinyl alcohol is optimized, combined with the film-forming properties of polyvinyl alcohol, to prepare a high-quality composite film. When the nanocellulose content reached 0.8 %, the tensile stress reaches the maximum value, and the composite film is not easily torn. The addition of NCC reduces the crystallinity of the PVA component and increases the initial decomposition temperature of the alcohol-nanocellulose composite film. The thermal decomposition rate of the PVA/NCC composite film is slightly lower than that of the pure PVA film, indicating that the addition of NCC improves the heat resistance of the PVA film. The electron microscope results show that PVA has good compatibility with NCC. The release results of tetracycline hydrochloride showed that when the nanocellulose content reached 0.8 %, the loading rate reached 83.07 %. R2 value of the two materials is 0.99 under the zero-order model fitting, which suggest the release process is transported by Supercase-II transport kinetics. Through the inhibition zone and cytotoxicity, it is proved that this material has a certain bacteriostatic effect and good cytocompatibility.