Abstract
Brown seaweed polysaccharides (BSPs) are one of the primary active components from brown seaweed that has a range of pharmaceutical and biomedical applications. However, the quality control of BSPs is a challenge due to their complicated structure and macromolecule. In this study, saccharide mapping based on high-performance liquid chromatography (HPLC), multi-angle laser light scattering, viscometer, and refractive index detector (HPSEC-MALLS-Vis-RID), and Fourier transform infrared (FT-IR) were used to discriminate the polysaccharides from nine different species of brown algae (BA1-9). The results showed that BSPs were composed of β-D-glucans and β-1,3−1,4-glucan linkages. The molecular weight, radius of gyration, and intrinsic viscosity of BSPs were ranging from 1.718 × 105 Da to 6.630 × 105 Da, 30.2 nm to 51.5 nm, and 360.99 mL/g to 865.52 mL/g, respectively. Moreover, α values of BSPs were in the range of 0.635 to 0.971, which indicated a rigid rod chain conformation. The antioxidant activities of BSPs exhibited substantial radical scavenging activities against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2, 2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) radicals, which indicated that the use of BSPs might be a potential approach for antioxidant supplements. Thus, this study gives insights about the structure-function relationship of BSPs, which will be beneficial to improve the quality of polysaccharides derived from marine algae.
Highlights
Brown seaweed is a potentially renewable resource in the marine environment
The results were the sum of the peak area of oligosaccharides-PMP derivative detected by high-performance liquid chromatography (HPLC)-diode array detector (DAD)
The results showed that polysaccharides in Brown seaweed polysaccharides (BSPs) mainly consist of mannose, glucuronic acid, glucose, galactose, and fucose, with small amounts of rhamnose and arabinose
Summary
Brown seaweed is a potentially renewable resource in the marine environment. It is one of the significantly farmed alga species along with the Asia coast, which has been used in traditional medicine for a long time [1]. As an excellent source of bioactive compounds such as carotenoids, dietary fibre, protein, essential fatty acids, vitamins, and minerals, brown seaweed is potentially exploited as functional ingredients for both human and animal health applications [2, 3]. This seaweed contains a large amount of carbohydrate as structural, storage, and functional polysaccharide, with the total carbohydrate content ranging from 50 to 60% of dry weight [4]. Brown seaweed polysaccharides (BSPs) have become the focus of interest They are known to be an excellent resource with valuable biological activities finding applications as functional foods, pharmaceuticals, and cosmeceuticals. To promote further exploitation and full utilization of BSPs for functional food and pharmaceutical applications, a basic understanding of BSPs’physicochemical properties and biological activities need to be investigated
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