Abstract
2-Aminopyridine is an important compound, which is used as intermediate for the synthesis of pharmaceutical compounds. The present work was aimed to assess the effect of Mr. Trivedi’s biofield energy treatment on the physical, thermal and spectral characteristics of 2-AP. The work was accomplished by dividing the sample in two parts <i>i.e.</i> one part was remained untreated, and another part had received biofield energy treatment. Subsequently, the samples were analyzed using various characterization techniques such as X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, ultra violet-visible spectroscopy, and Fourier transform infrared spectroscopy. The XRD analysis revealed a decrease in crystallite size of the treated sample (91.80 nm) as compared to the control sample (97.99 nm). Additionally, the result showed an increase in Bragg’s angle (2θ) of the treated sample as compared to the control. The DSC and Differential thermal analysis analysis showed an increase in melting temperature of the treated 2-AP with respect to the control. Moreover, the latent heat of fusion of the treated sample was increased by 3.08%. The TGA analysis showed an increase in onset of thermal degradation (T<sub>onset</sub>), and maximum thermal decomposition temperature (T<sub>max</sub>) of the treated 2-AP as compared to the control sample. Additionally, the treated sample showed a reduction in weight loss as compared with the control indicating higher thermal stability of the sample. UV-visible analysis showed no changes in the absorption peak of the treated sample as compared to the control. The FT-IR spectroscopic results showed downward shifting of C-H stretching vibration 2991→2955 cm<sup>-1</sup> in treated sample with respect to the control.
Highlights
Aminopyridines are an important class of compounds used as a research tool for characterizing subtypes of the potassium channel [1]. 4-Aminopyridine or fampridine is used as a drug for symptomatic treatment of multiple sclerosis and it is believed to improve the walking in adults with several variations of the disease [1, 2]
It acts by blocking the potassium channels and prolong the action potentials, thereby releases neurotransmitters at the neuromuscular junction [3]. 2-Aminopyridine (2-AP) is one of the isomers of aminopyridines and it has been used for the synthesis of pharmaceutical agents [4]. 2-AP is a colourless solid used in the production of piroxicam, which is used as a non-steroidal anti-inflammatory drug (NSAID) to relieve the symptoms of painful, inflammatory conditions like arthritis [5, 6]
It is assumed that tensile stress might be applied in the treated sample due to biofield energy treatment that caused an increase in 2θ angle of the X-Ray Diffraction (XRD) peak as compared to the control
Summary
Aminopyridines are an important class of compounds used as a research tool for characterizing subtypes of the potassium channel [1]. 4-Aminopyridine or fampridine is used as a drug for symptomatic treatment of multiple sclerosis and it is believed to improve the walking in adults with several variations of the disease [1, 2]. 4-Aminopyridine or fampridine is used as a drug for symptomatic treatment of multiple sclerosis and it is believed to improve the walking in adults with several variations of the disease [1, 2] It acts by blocking the potassium channels and prolong the action potentials, thereby releases neurotransmitters at the neuromuscular junction [3]. 2-AP is a colourless solid used in the production of piroxicam, which is used as a non-steroidal anti-inflammatory drug (NSAID) to relieve the symptoms of painful, inflammatory conditions like arthritis [5, 6] It has been used as an intermediate for the synthesis of pharmaceutical agents such as sulfapyridine, tenoxicam, and tripelennamine [4]. 2-AP based compounds have been evaluated for the treatment of Alzheimer’s and neuro vascular diseases [11]
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