Abstract
The rat has been considered as an appropriate animal model for the study of the mineralization process in humans. In this work, we found that the phosphorus species in human dentin characterized by solid-state NMR spectroscopy consist mainly of orthophosphate and hydrogen phosphate. Some orthophosphates are found in a disordered phase, where the phosphate ions are hydrogen-bonded to structural water, some present a stoichiometric apatite structure, and some a hydroxyl-depleted apatite structure. The results of this study are largely the same as those previously obtained for rat dentin. However, the relative amounts of the various phosphorus species in human and rat dentin are dramatically different. In particular, stoichiometric apatite is more abundant in human dentin than in rat dentin, whereas the converse is true for disordered-phase orthophosphates. Furthermore, spatial proximity among all phosphorus species in human dentin is identical within experimental error, in contrast to what observed for rat dentin. Although it is not clear how these spectroscopic data could relate to the hierarchical structure or the mechanical properties of teeth, our data reveal that the molecular structures of human and rat dentin at different growth stages are not exactly the same.
Highlights
Bone and teeth are the major calcified tissues in the human body
In our previous works [9,10,11], we studied a series of dentin samples taken from Wistar rats using solid-state NMR spectroscopy
We found that the distribution of the three mineral phases was rather phases was rather different from that observed in rat dentin
Summary
Bone and teeth are the major calcified tissues in the human body. The human tooth contains three major parts, viz., enamel, dentin, and cementum [1]. It is not trivial to disordered-phase calcium phosphate In this regard, solid-state NMR spectroscopy, which is nondistinguish poorly crystallized apatite from highly disordered-phase calcium phosphate. Solid-state NMR spectroscopy, which is nondistinguish poorly crystallized apatite from highly disordered-phase calcium phosphate In this regard, invasive and inherently quantitative, has been proven to be a powerful analytical technique for the solid-state NMR spectroscopy, which is non-invasive and inherently quantitative, has been proven to study of bone and teeth [6,7,8]. In our previous works [9,10,11], we studied a series of dentin samples taken from Wistar rats using solid-state NMR spectroscopy. Human dentin was qualitatively different from that of rat dentin
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