Abstract
The solvent evaporation of ibuprofen, Avicel, and Aerosil in selected ratios were evaluated for particle packing and rearrangement and drug release. Physicochemical characterization was carried out by using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Transitional tapping between primary rearrangement and secondary rearrangement was found to be 20–30 taps with native ibuprofen powder and up to 45 taps with all formulated powders. Particle packing in the rearrangement stage was increased for all the formulations with respect to ibuprofen alone. Combination of Avicel and Aerosil brought about partial amorphization of the drug and improved wettability after solvent evaporation. Significantly improvement of packing of ibuprofen in rearrangement stage has been achieved by solvent evaporation of ibuprofen, Avicel, and Aerosil, which brought about improved release of drug from all formulated tablets.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
