Abstract
The antagonism of PAF effects by WEB 2086 and the receptor binding of [ 3H]WEB 2086 were investigated in isolated human neutrophils. WEB 2086 inhibited PAF-induced β-glucuronidase release and [ 3H]WEB 2086 bound specifically to high-affinity sites on the cells. Close concordance between affinity constants for WEB 2086 from functional and radioligand-binding studies suggests that WEB 2086 interacts with the neutrophil PAF receptors and that [ 3H]WEB 2086 may be a useful ligand in investigation of these receptors.
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