Abstract
NMR is a powerful characterization tool and we propose to study the surface of silica or bismuth nanoparticles dedicated to medical applications in order to evidence the covalent grafting of organic molecules on their surface. For that aim, DOSY experiments are particularly useful and allow for the discrimination of molecules interacting strongly with the nanoparticle surface from molecules simply weakly adsorbed at the surface. We were able to characterize thoroughly the surface of different silica and bismuth nanoparticles.
Highlights
Nanoparticles (NP) are more and more explored for applications in the medical field.They can be used as drug delivery systems and as contrast agents for different imaging techniques
In addition to the classical 1D and 2D Nuclear Magnetic Resonance (NMR) spectra, diffusion ordered spectroscopy (DOSY) experiments are useful for these type of investigations [2,3,4]
As the covalent grafting of the gadolinium chelates at the nanoparticle surface is the key to obtain a high efficacy of the entity, the characterization of this binding is of crucial importance and we propose to describe an NMR method allowing this investigation
Summary
Nanoparticles (NP) are more and more explored for applications in the medical field.They can be used as drug delivery systems and as contrast agents for different imaging techniques. In addition to the classical 1D and 2D NMR spectra, diffusion ordered spectroscopy (DOSY) experiments are useful for these type of investigations [2,3,4]. It allows the determination of the diffusion coefficients of the solution species and will allow to discriminate between covalently grafted ligands and adsorbed ligands. If the ligand is adsorbed on the nanoparticle surface, an average diffusion coefficient between those of the free and of the bound ligand should be observed because of the fast exchange between these two species (Equation (1))
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