Characterization of Optical System for Hemodynamic Multi-Parameter Assessment

Abstract

Cardiovascular diseases are a growing epidemiological burden in today’s society. A great deal of effort has been made to find solutions able to perform non-invasive monitoring and early diagnosis of such pathologies. The pulse wave velocity and certain waveform characteristics constitute some of the most important cardiovascular risk indicators. Optical sensors are an attractive instrumental solution in this kind of time assessment applications due to their truly non-contact operation capability and better resolution than commercial devices. This study consisted on the experimental validation and a clinical feasibility for a non-invasive and multi-parametric optical system for evaluation of the cardiovascular condition. Two prototypes, based on two different types of photodetectors (planar and avalanche photodiode) were tested in a small group of volunteers, and the main hemodynamic parameters were measured, such as pulse wave velocity and indexes of pulse waveform analysis: the Augmentation Index, Subendocardial Viability Ratio and Ejection Time Index. The probes under study proved to be able to measure the pulse pressure wave in a reliable manner at the carotid site, and demonstrated the consistency of the parameters determined using dedicated algorithms. This study represents a preliminary evaluation of an optical system devoted to the clinical evaluation environment. Further development to take this system to a higher level of clinical significance, by incorporating it in a multicenter study, is currently underway.