Abstract
Meeting abstracts Response to immunotherapies and improved survival are linked to a T cell-inflamed tumor microenvironment, which is characterized by expression of a chemokine and type I interferon gene signature and the presence of CD8+ tumor-infiltrating T cells. In urothelial bladder cancer,
Highlights
Response to immunotherapies and improved survival are linked to a T cell-inflamed tumor microenvironment, which is characterized by expression of a chemokine and type I interferon gene signature and the presence of CD8+ tumor-infiltrating T cells
Characterization of oncogenic pathways linked with T cell exclusion in urothelial bladder cancer
We found no difference in mutational density between groups (P = 0.80, two-sided t-test)
Summary
Response to immunotherapies and improved survival are linked to a T cell-inflamed tumor microenvironment, which is characterized by expression of a chemokine and type I interferon gene signature and the presence of CD8+ tumor-infiltrating T cells. Characterization of oncogenic pathways linked with T cell exclusion in urothelial bladder cancer From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. Durable responses to PD1-targeted immunotherapies have been reported, yet the majority of patients still do not benefit clinically.
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