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Abstract
Publisher Summary This chapter discusses the characterization of NIMA protein kinase in Aspergiuus nidulans. The Aspergillus nidulans NIMA protein kinase is the founding member of a growing family of protein kinases now isolated from many eukaryotic organisms ranging from fungi to humans. Members of this family of kinases all have an N-terminal kinase domain, a long, highly basic, C-terminal extension, and a high isoelectric point (>10). Members of this family studied to date all show a clear preference for/5-casein as in vitro substrate. Among all members of this kinase family the best characterized both molecularly and biochemically is the A. nidulans NIMA kinase. The molecular and biochemical properties of the A. nidulans NIMA kinase are summarized in this chapter. In A. nidulans, NIMA kinase is essential for entry into mitosis, and to initiate mitosis coordinate activation of both p34 Cdc2 and NIMA kinase is required.
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