Abstract
BackgroundThe most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the association of infection with Beijing genotype M.tb with population characteristics, in Beijing, however, are still unclear.MethodsIn this retrospective study, 1189 isolates were subjected to drug susceptibility testing (DST) and molecular epidemiological analysis, and differences in the percentage of drug resistance between Beijing and non-Beijing genotype strains were compared. The association between the occurrence of drug resistance and the prevalence of Beijing genotype M.tb was analyzed using statistical methods.ResultsThe Beijing genotype family was the dominant genotype (83.3%) among the 1189 M.tb isolates. Beijing genotype M.tb strains were more likely to spread among males [p = 0.018, OR (95% CI):1.127(1.004–1.264)] and people in the 45–64 age group [p = 0.016, OR (95% CI): 1.438 (1.027–2.015)]. On the contrary, non-Beijing genotype M.tb strains were more probably disseminated among the over 65 [p = 0.005, OR (95% CI):0.653 (0.474–0.9)] and non-resident population [p = 0.035, OR (95% CI):1.185(0.985–1.427)]. DST results showed that 849 (71.4%) strains were fully sensitive to first-line drugs, while 340 (28.6%) strains were resistant to at least one drug, and 9% (107/1189) were MDR-TB. The frequency of INH-resistance among Beijing genotype strains was significantly lower than that among non-Beijing genotype strains (p = 0.032). In addition, the Beijing genotype family readily formed clusters.ConclusionsOur findings indicate that male and middle-aged people were more probably be infected by Beijing genotype M.tb, older people and non-residents were more probably be infected by non-Beijing genotype M.tb. The high percentage of resistance to INH occurring in non-Beijing genotype strains suggested that non-Beijing genotype strains should be given much more interest in Beijing.
Highlights
The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family
To clarify if there is an association between the Beijing genotype and resistance to anti-TB drugs, we investigated drug susceptibility patterns in Beijing genotype and non-Beijing genotype strains of M.tb strains in Beijing, comparing differences in patterns of drug resistance, and analyzing the relationship between genotype patterns and drug susceptibility testing (DST) results
We found that Beijing genotype M.tb strains were more probably be isolated from men [p = 0.018, Odd ratios (ORs) (95%confidence intervals (CI)):1.127(1.004–1.264)]and people in the 45–64 age group [p = 0.016, OR: 1.438 (1.027–2.015)]
Summary
The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. Tuberculosis (TB) is an infectious disease and a significant global public health problem [1, 2]. There were an estimated 10.1 million incident TB cases worldwide in 2017 [3], of which about 6.4 million were notified. The TB incidence rate and the case fatality ratio have fallen, TB continues to be a public health problem in China [3]. TB is a public health problem in Beijing, the capital of the People’s Republic of China [4]. There is a need for more studies to clarify the association between drug resistance and genotype diversity in Beijing, in particular to, investigate the relationship between drug resistance and Beijing genotype family strains
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