Characterization of Mutagenicity Test and Identification of N-Nitroso Mutagens in Some Soju Alcoholic Spirits

Abstract

Excision repair after combined treatments of UV and N-acetoxy-2-acetylaminofluorene (AAAF) was studied by three different techniques in cells proficient in UV excision repair and in cells deficient in UV repair. Two patterns of repair were observed: A) in repair proficient cells total repair was additive, and B) in repair deficient cells total repair was much less than additive—usually less than observed for separate treatments—and AAAF inhibited dimer excision. We conclude that in the 1st class of cells pathways for repair of UV and AAAF lesions are not identical, and in the 2nd class the residual excision enzymes are different from those in repair proficient cells.