Abstract
Nasal drug delivery systems prepared from natural materials are gaining importance in the field of pharmaceutical technology. Mucilage isolated from Linum usitatissimum L. (LUM) seeds was reported to be an effective natural mucoadhesive agent. The present study deals with a comparison of various characteristics of nasal gels containing midazolam hydrochloride (HCl) prepared from mucoadhesive agent extracted from Linum usitatissimum L. seeds and synthetic polymers like HPMC and Carbopol 934P in terms of texture profile analysis, mucoadhesive strength, and in vivo drug absorption profiles. It was observed that gels formulated with the natural mucilage showed better results than the synthetic gels in all aspects like hardness, adhesiveness, cohesiveness and mucoadhesive strength. The absolute bioavailability of midazolam hydrochloride from the natural gel was 97.55% whereas that of synthetic gels was 57.33% and 76.81% respectively.
Highlights
Mucoadhesive nasal gels provide a firmer platform of drug delivery to the nasal cavity than other types of nasal formulations like solutions, sprays and insufflations, since the mucoadhesive agents make a better contact with the nasal mucosa, which helps enhancing drug bioavailability
Mucoadhesive nasal gels of midazolam were prepared from mucilages isolated from Linum usitatissimum L. seeds and it was observed that they gave better results than synthetic polymers in terms of viscosity and in vitro release profiles (Basu et al, 2009)
The present study focuses on the preparation of mucoadhesive nasal gels containing midazolam hydrochloride (HCl) and on a comparison of texture profile analyses, mucoadhesive strengths and in vivo drug absorption profiles from nasal gels prepared with mucilage isolated from Linum usitatissimum L. seeds and synthetic polymers like HPMC and Carbopol 934P
Summary
Mucoadhesive nasal gels provide a firmer platform of drug delivery to the nasal cavity than other types of nasal formulations like solutions, sprays and insufflations, since the mucoadhesive agents make a better contact with the nasal mucosa, which helps enhancing drug bioavailability. Mucoadhesive nasal gels of midazolam were prepared from mucilages isolated from Linum usitatissimum L. seeds and it was observed that they gave better results than synthetic polymers in terms of viscosity and in vitro release profiles (Basu et al, 2009). It has been reported that the presence of many oligo- and polysaccharides in many substances imparts mucoadhesive properties (Hunt et al, 1962) Since this mucilage is a rich source of polysaccharides and has remarkable swelling capacity and high viscosity, it was selected to prepare nasal gels of midazolam. The present study focuses on the preparation of mucoadhesive nasal gels containing midazolam hydrochloride (HCl) and on a comparison of texture profile analyses, mucoadhesive strengths and in vivo drug absorption profiles from nasal gels prepared with mucilage isolated from Linum usitatissimum L. seeds and synthetic polymers like HPMC and Carbopol 934P
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