Abstract
AbstractHighly proliferative cancer cells maintain high rates of glycolysis, producing large amounts of acids, mainly lactic acid. Despite this fact, only the interstitial pH of tumours is low, while the intracellular pH of tumours is either normal or higher than that of normal tissues. Monocarboxylate transporters (MCTs) are transmembrane proteins that, by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. MCTs play a central role in cellular metabolism and are essential for the transport of metabolically important monocarboxylates, such as lactate, across the plasma membrane.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
