Abstract
Net Mg 2+ efflux from Mg 2+-loaded human, rat and chicken erythrocytes was measured in sucrose, NaCl and choline Cl medium. Thus, Na +-dependent (NaCl minus choline Cl) and Na +-independent Mg 2+ efflux (in sucrose) were determined. Na +-dependent Mg 2+ efflux amounted to 0.16, 8.9 and 1.57 mmol/l cells × 30 min, Na +-independent Mg 2+ efflux amounted to 0.89, 1.55 and 0.37 mmol/l cells × 30 min for human, rat and chicken erythrocytes. Na +-dependent Mg 2+ efflux was inhibited by quinidine. Na +-independent Mg 2+ efflux was inhibited by SITS and Cl −. A small fraction of Na +-independent Mg 2+ efflux (in choline Cl) was resistant to SITS and Cl −. Ca 2+ loading increased Mg 2+ efflux similar to K + efflux (Gardos effect). This effect was differently expressed in human and chicken erythrocytes.
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