Abstract
Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC50 (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown.
Highlights
The year 2020 focused the scientific community on the COVID-19 pandemic [1,2,3]
It is clear from the FTIR data that N-donors act as monodentate ligands in complexes C1, C2, and C4
It Study is clear from the FTIR data that N-donors act as monodentate ligands in com3.4
Summary
The year 2020 focused the scientific community on the COVID-19 pandemic [1,2,3]. The pandemic has accelerated the search for new drugs, not forgetting one of the most deadly cancers—lung cancer. The main goal was to inhibit the number of diseases and the spread of the virus while looking for drugs for existing diseases [4,5,6,7]. Scientists around the world have been searching and are still looking for pharmaceutical compounds with potential antifungal, antibacterial, anticancer, and antiviral properties, with particular emphasis on coronavirus (2019-nCoV), which emerged in Wuhan, China [8,9,10]. People with cancer are more likely to experience severe COVID-19 and dangerous complications. Treatments are delayed, pain medications are lacking, and some cancer-related clinical trials are stopped
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