Characterization of Mannose Binding Lectin Levels In Type 2 Diabetes Mellitus Among Pakistani Population

Abstract

Introduction: Increased mortality and morbidity have been associated with type 2 Diabetes due to increased risk of complications among patients with poor glycemic control. Studies reveal a mixed association of Mannose Binding Lectin (MBL) with complications and poor outcome in diabetics. Here we sought to characterize serum levels of MBL and their association with clinical parameters in type 2 diabetes patients compared to healthy controls in Pakistani Population. Methods: A Cross-sectional study was performed at Chughtai Lab Lahore. The study groups included Type 2 diabetes patients (80 Females; 120 Males) and healthy controls (51 Females; 49 Males). Fasting blood samples were analyzed for creatinine, hs-CRP, HbA1c, ALT, Cholesterol, HDL-C, LDL-C, Triglyceride, Glucose and Serum MBL. All analytes except MBL were measured by fully automated chemistry analyzer. Serum levels of MBL were measured using ELISA. Results: Mean MBL levels among the healthy controls and the diabetic group were 110.1±3.944pg/ml and 197.9±12.840pg/ml, respectively (p<0.05). The concentration of Fasting Glucose, HbA1c, LDL-C, HDL-C, Triglyceride, eGFR and creatinine among diabetics were significantly different from those of healthy controls (p<0.05). Serum MBL levels in healthy controls correlated negatively with plasma glucose and positively with HDL-C. Diabetic patients with MBL level above 178pg/ml had positive correlation with HbA1c. The ratio of Trig/HDL was higher in the diabetic group with MBL above 178pg/ml and positively correlated with MBL. Conclusion: A significant association of MBL with HbA1c and Trig/HDL-C ratio suggests a possible relationship of MBL with glycemic control and development of cardiovascular complications in type 2 diabetics.