Abstract
The ionotropic glutamate (iGlu) receptors mediate fast excitatory synaptic transmission in the central nervous system (CNS). The iGlu receptors are crucial for normal brain function and are involved in a range of neurological and psychiatric diseases for which iGlu receptors are considered potential therapeutic drug targets. Polyamine toxins are a group of small molecules isolated from spiders and wasps and have been found to act as potent inhibitors of mammalian iGlu receptors. Subfamily and subtype selective polyamine toxins provide a valuable pharmacological tool to study the contribution of individual iGlu receptors in both physiological and neuropathological conditions.
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