Abstract
The aim of the present study was to evaluate the probiotic potential of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02, two strains isolated from canine milk. These two isolates were characterized in vitro for their survival to conditions similar to those found in the canine gastrointestinal tract, production of antimicrobial compounds, adherence to intestinal mucin, degradation of mucin, and antibiotic sensitivity. Globally, both strains exhibited a high in vitro probiotic potential. Finally, their potential for the prevention of gastrointestinal infections was evaluated in an experimental canine model using 1-month-old puppies. A group of 12 German shepherd puppies, 6 males and 6 females, received L. rhamnosus MP01 daily for 2 months and a second group of 12 puppies, 6 males and 6 females, of the same breed received L. plantarum MP02 during the same period of time. The same experimental approach was carried with Yorkshire puppies. Additionally, the trial included 12 dogs of each breed in the placebo groups. The results demonstrated that administration of the strains resulted in a significant preventive effect of gastrointestinal infections in such populations.
Highlights
Infectious gastroenteritis is one of the most common conditions in canine practice, being frequent among puppies
Since both species are included in the qualified presumption of safety (QPS) list (European Food Safety Authority [EFSA], 2017), they were submitted to a further characterization
Intestinal-like secretion had no effect on the population of both lactobacilli strains
Summary
Infectious gastroenteritis is one of the most common conditions in canine practice, being frequent among puppies. The first concern is the potential development and spread of antibiotic-resistant bacteria that may compromise the treatment of animal and Probiotic Prevention of Canine Gastroenteritis human infectious diseases in the future (Lloyd, 2007). Isolation of antibiotic-multiresistant strains as agents of nosocomial infections in dogs hospitalized in intensive care units is increasing (Guardabassi et al, 2004) and involves species as relevant as Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli, or Salmonella enterica. The transmission of such organisms may occur between pets but, between pets, owners and veterinary personnel (Manian, 2003; Gandolfi-Decristophoris et al, 2013)
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