Abstract
Kinesin family member 2C (KIF2C) is known as an oncogenic gene to regulate tumor progression and metastasis. However, its pan-cancer analysis has not been reported. In this study, we comprehensively analyzed the characteristics of KIF2C in various cancers. We found that KIF2C was highly expressed and corresponded to a poor prognosis in various cancers. We also found a significant correlation between KIF2C and clinicopathological characteristics, particularly in cervical cancer, which is the most common gynecological malignancy and is the second leading cause of cancer-related deaths among women worldwide. KIF2C mutation is strongly associated with the survival rate of cervical cancer, and KIF2C expression was significantly upregulated in cervical cancer tissues and cervical cancer cells. Moreover, KIF2C promoted cervical cancer cells proliferation, invasion, and migration in vitro and as well increased tumor growth in vivo. KIF2C knockdown promotes the activation of the p53 signaling pathway by regulating the expression of related proteins. The rescue assay with KIF2C and p53 double knockdown partially reversed the inhibitory influence of KIF2C silencing on cervical cancer processes. In summary, our study provided a relatively comprehensive description of KIF2C as an oncogenic gene and suggested KIF2C as a therapeutic target for cervical cancer.
Highlights
Kinesin family member 2C (KIF2C), known as mitotic centromere associated kinesin (MCAK), is the most representative member of the kinesin family-13 (Kinesin-13) (Ritter et al, 2015)
In the TIMER database, we investigated the expression of KIF2C in pan-cancer
We used the UALCAN database to analyze the correlation between KIF2C messenger RNA (mRNA) expression and clinicopathological stages
Summary
Kinesin family member 2C (KIF2C), known as mitotic centromere associated kinesin (MCAK), is the most representative member of the kinesin family-13 (Kinesin-13) (Ritter et al, 2015). It participates in the functions of microtubules and regulates mitosis and cell cycle, involving in the disaggregation and formation of secondary spindles and the separation of chromosomes (DeLuca et al, 2006; Ganguly et al, 2008; Hedrick et al, 2008; Huang et al, 2009). Because KIF2C is involved in the regulation of tumor development, proliferation, and metastasis, it has been considered as a candidate promoting factor for breast cancer, liver cancer, lung cancer, bladder cancer, colon cancer, and other cancers (Bai et al, 2019; Wei et al, 2020; Yang et al, 2020). Yang et al (2020) showed that circRGNEF promotes the occurrence and development of bladder cancer by directly targeting miR-548 and upregulating the expression of KIF2C
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