Abstract
We have described a paradoxical upregulation of human renin mRNA in the kidney of transgenic mice containing both human renin and angiotensinogen genes (double transgenic). These mice exhibit hypertension and increased levels of angiotensin II (AII). In contrast, expression of the endogenous mouse renin gene decreased as expected in response to these stimuli.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
