Abstract
A procedure for structural analysis of normal and variant human hemoglobins by using fast atom bombardment mass spectrometry is described. The methodology consists of direct mass spectrometric analysis of proteorytic digests of the variant globin; peptide recognition along the globin chain sequence is accomplished on the basis of their molecular weight. The abnormal peptide(s) will exhibit a mass value different from those of the normal hemoglobin, allowing easy definition of the structural variations. The application of this procedure to the determination of normal globin chains as well as to known and unknown abnormal human hemoglobins is reviewed.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
